MedBytes – Methotrexate
Side-effects of methotrexate got you down?
Before switching or adding a new drug, check with your doctor to see if any of the following are right for you:
Changing from oral to an injection (normally more expensive).

It may be possible to break up your full weekly dose into two separate doses and times.
Example, if you take 6 tablets once weekly, ask if you can take 3 tablets the night you normally do, and 3 more the next morning about 12 hours later. Still once a week, but in two doses 12 hours apart each week.
Also, to limit methotrexate side-effects, daily or weekly folic acid use is advised*.
*Note – this information is only for methotraxate use in Rheumatoid arthritis. If you take methotrexate for cancer purposes, folic acid use is only recommended if your doctor says it’s safe.
